Exercise and caffeine can help prevent skin
cancer.
The combination can also be effective
against inflammation caused by other cancers that are linked to obesity, the
American Association for Cancer Research's (AACR) annual meeting heard.
A recent study has found that people who
drink three or more cups of coffee a day have a 20% lower risk of basal cell
carcinoma, the most common form of skin cancer.
Dr Yao-Ping Lu, associate research
professor of chemical biology and Rutgers Ernest Mario School of Pharmacy's
director of skin cancer prevention, addressed the meeting in Chicago.
He says, "We found that this
combination treatment can decrease sunlight-caused skin cancer formation in a
mouse model.
"I believe we may extrapolate these
findings to humans and anticipate that we would benefit from these combination
treatments as well."
Researchers analyzed data from the famous
Nurses' Health Study on more than 112,000 people. One fourth of those studied
had developed basal cell carcinoma over a 20 year period. Investigators found
the more someone drank caffeinated coffee, (more than two cups a day) the lower
their risk of developing this form of cancer.
The study team tested the effects of
exercise and caffeine on mice that had a large risk of skin cancer.
The mice that were given caffeine and took
exercise in a wheel had almost two-thirds (62%) fewer incidents of skin cancer.
The volume of tumours fell by 85% compared with mice that had no exercise or
caffeine.
By taking either exercise or caffeine,
fewer positive effects were experienced. There was a 27% fall in tumours and a
61% fall in their size when caffeine was taken. In those mice that exercised,
the incidence of tumours fell 35% and the volume by 70%.
It was also found that caffeine and
exercise cut weight and swelling. Mice were fed a diet rich in omega-6 fatty
foods and fat levels around the parametrium, the largest area of fat in a
mouse, were calculated after a fortnight of exercise or caffeine doses.
Mice that had both caffeine and exercise
treatment saw their fat pad weight fall 63%. Those taking just exercise had a
56% fall and those with caffeine doses saw a 30% reduction. The size and rate
of development of the cancer also fell.
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